P-21 Peptide

A synthetic neurotrophic-style peptide derived from the active region of Ciliary Neurotrophic Factor (CNTF), designed for research into neurogenesis, cognitive support, and neuronal repair.

Key Identifiers & Facts

How It Works 

• It mimics a small fragment of CNTF to trigger signalling pathways tied to neuronal survival and growth.
• By potentially enhancing neuronal plasticity and growth factor expression, it may support brain resilience under stress. 
• Early studies indicate benefits in neural tissue models for repair and structural support. 

Potential Applications & Research Highlights

• Supports neurogenesis—early animal/ in-vitro models show increased marker expression for new neuron formation. 
• May support cognitive function and resilience in models of neuronal injury or degeneration. 
• Because it is a small fragment engineered for CNS uptake, it opens pathways for brain-focused peptide research beyond larger neurotrophins

• Primarily preclinical data—human clinical trials are limited or not publicly published.
• As with any neuro-active peptide, effects may vary and caution is advised in research protocols.

Synergistic Peptides

• Pair with cognitive/neuro-repair peptides such as Semax or Selank for broader neural support.
• Combine with antioxidant/mitochondrial support peptides (e.g., Methylene Blue formulations) for enhanced neuronal environment optimisation.

*For research-use only. Not approved for therapeutic use. Always consult primary literature and ensure ethical protocols when working with neuro-active peptides.